Adaptive optical system distortion technology for medical HD imaging

The emergence of real-time 3D microscopic imaging technology is a revolution in the medical field of cancer diagnosis, minimally invasive surgery and ophthalmology. According to a report by the Physicist Network on April 23, researchers at the University of Illinois in the United States have developed distortion techniques for correcting optical tomography using computational adaptive optics to bring future prospects for medical "HD" imaging. Relevant technical achievements are published in the latest issue of the Journal of the National Academy of Sciences.

Stephen, a postdoctoral fellow in advanced science and technology at the Beckman Institute in the United States, said: "This technology can surpass the current optical system and ultimately achieve the best quality images and 3D data. This will be a very useful real-time imaging technology."

Distortion such as astigmatism or distortion plagues high resolution imaging. It will make the object's fine spots look like spots or stripes. The higher the resolution, the worse the problem becomes. This is a particularly difficult problem in tissue imaging, and accuracy is critical for proper diagnosis.

Adaptive optics can correct imaging distortion and is widely used in astronomy to correct deformation of the starlight filter through the atmosphere. Medical scientists have begun to apply the hardware of this adaptive optics system to the microscope, hoping to improve cell and tissue imaging.

But Stephen, a professor of electrical and computer engineering at Bioengineering Internal Medicine at the University of Illinois, points out that it is equally challenging to apply it to tissue and cell imaging, rather than imaging the stars through the atmosphere, and there are many optical problems. The hardware-based adaptive optics system is complex and expensive, and the adjustment is cumbersome, so it is not suitable for medical scanning.

As a result, the team used computer software to discover and correct image distortion, replacing hardware adaptive optics, called computational adaptive optics. Using this technique, the researchers demonstrated the phantom of rat lung tissue containing microscopic particle gels. The optical imaging device interferes with the two beams of the microscope to scan the tissue sample. After the computer collects all the data, it corrects all the depth images, making the blurred stripes become sharp points and the features appear, and the user can change the parameters with a mouse click. The researchers said: "We were able to correct the distortion of the entire study volume and present high-resolution images anywhere. From this, we can now see all the organizational structures that were not well understood before."

The technology can be applied to desktop computers in many hospitals and clinics for interference imaging of any type, such as optical coherence tomography.

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